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pentobarbital will minimize the extent or outcome of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers raise amount of toremifene metabolism, reducing the constant-point out concentra